Motohiro Okada Selected Research

Cognitive Dysfunction

6/2022	Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems.
4/2022	Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain.
4/2021	Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions.
11/2020	Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine.
5/2020	Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor.
10/2019	Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report.
1/2019	Effects of acute and sub-chronic administrations of guanfacine on catecholaminergic transmissions in the orbitofrontal cortex.
1/2019	Memantine protects thalamocortical hyper-glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc<sup/>.

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Motohiro Okada Research Topics

Disease

20	Epilepsy (Aura) 05/2022 - 01/2002
16	Schizophrenia (Dementia Praecox) 01/2023 - 06/2004
10	Seizures (Absence Seizure) 01/2020 - 01/2004
9	Mood Disorders (Mood Disorder) 01/2023 - 12/2002
8	Cognitive Dysfunction 06/2022 - 01/2019
7	Panic Disorder (Panic Attack) 01/2021 - 09/2007
7	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 11/2015 - 01/2002
5	Weight Gain 03/2023 - 04/2022
5	Treatment-Resistant Schizophrenia 01/2023 - 01/2019
5	Pain (Aches) 12/2021 - 02/2007
4	Pathologic Constriction (Stenosis) 12/2023 - 10/2009
3	Lordosis 10/2023 - 10/2017
3	Neuroleptic Malignant Syndrome 01/2012 - 01/2010
3	Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions) 03/2009 - 09/2002
3	Febrile Seizures (Febrile Seizure) 01/2005 - 06/2002
2	Diffuse Idiopathic Skeletal Hyperostosis 09/2023 - 09/2022
2	Catatonia 01/2023 - 01/2012
2	Spinal Cord Compression 01/2022 - 05/2009
2	Spinal Cord Diseases 12/2021 - 10/2017
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2021 - 01/2019
2	Spondylolisthesis 01/2021 - 01/2019
2	Bipolar Disorder (Manic Depressive Psychosis) 12/2020 - 10/2020
2	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2014
2	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 10/2012
2	Absence Epilepsy (Childhood Absence Epilepsy) 11/2018 - 03/2013
2	Low Back Pain (Lumbago) 05/2014 - 02/2007
2	Intervertebral Disc Displacement (Herniated Disc) 05/2014 - 02/2007
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 03/2014 - 09/2002
2	Agoraphobia 04/2012 - 09/2007
2	Channelopathies 01/2012 - 01/2002
1	Osteophyte 12/2023
1	Scoliosis 10/2023
1	Body Weight (Weight, Body) 03/2023
1	Cardiotoxicity 01/2023
1	Cardiomyopathies (Cardiomyopathy) 01/2023
1	Heart Failure 01/2023
1	Rhabdomyolysis 01/2023
1	Pressure Ulcer (Bedsore) 06/2022
1	Central Cord Syndrome 06/2022
1	Pneumonia (Pneumonitis) 06/2022
1	Urinary Tract Infections (Urinary Tract Infection) 06/2022
1	Ossification of Posterior Longitudinal Ligament 01/2022
1	Necrosis 06/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 05/2021
1	Anxiety Disorders (Anxiety Disorder) 01/2021
1	Major Depressive Disorder (Major Depressive Disorders) 12/2020

Drug/Important Bio-Agent (IBA)

15	Antipsychotic Agents (Antipsychotics)IBA 03/2023 - 10/2009
7	Clozapine (Clozaril)FDA LinkGeneric 02/2023 - 01/2019
7	Glutamic Acid (Glutamate)FDA Link 06/2021 - 06/2004
6	gamma-Aminobutyric Acid (GABA)IBA 01/2023 - 06/2002
6	Anticonvulsants (Antiepileptic Drugs)IBA 06/2021 - 12/2002
6	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2020 - 01/2002
6	Cholinergic ReceptorsIBA 06/2020 - 11/2008
5	Lurasidone Hydrochloride FDA Link 03/2023 - 10/2019
5	N-Methylaspartate (NMDA)IBA 01/2023 - 01/2019
5	Connexin 43 (Connexin43)IBA 05/2022 - 03/2020
4	AcidsIBA 02/2023 - 02/2007
4	Antidepressive Agents (Antidepressants)IBA 01/2023 - 01/2020
4	Glutamate Receptors (Glutamate Receptor)IBA 06/2021 - 01/2019
4	Ion Channels (Ion Channel)IBA 01/2012 - 01/2002
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2023 - 06/2004
3	Carbamazepine (Tegretol)FDA LinkGeneric 05/2022 - 12/2002
3	Zonisamide (Zonegran)FDA LinkGeneric 01/2020 - 12/2002
3	Proteins (Proteins, Gene)FDA Link 10/2012 - 01/2012
3	Serotonin (5 Hydroxytryptamine)IBA 04/2012 - 02/2007
2	Quetiapine Fumarate (Seroquel)FDA Link 03/2023 - 10/2009
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 09/2022 - 02/2007
2	serotonin 7 receptorIBA 04/2022 - 10/2019
2	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 06/2021 - 07/2019
2	Adrenergic Receptors (Adrenergic Receptor)IBA 04/2021 - 01/2019
2	Guanfacine (Tenex)FDA LinkGeneric 04/2021 - 01/2019
2	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 01/2014
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2014 - 01/2014
2	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2014 - 03/2009
2	Messenger RNA (mRNA)IBA 11/2013 - 06/2005
2	GABA Receptors (GABA Receptor)IBA 06/2010 - 09/2002
2	Neurotransmitter Agents (Neurotransmitter)IBA 10/2009 - 06/2005
2	Hemoglobins (Hemoglobin)IBA 03/2009 - 09/2007
1	TitaniumIBA 09/2023
1	polyetheretherketoneIBA 09/2023
1	Thrombin FDA Link 04/2023
1	GelatinIBA 04/2023
1	brexpiprazoleIBA 02/2023
1	AMP-Activated Protein KinasesIBA 02/2023
1	VortioxetineIBA 01/2023
1	Olanzapine (Zyprexa)FDA Link 01/2023
1	Insulin (Novolin)FDA Link 01/2023
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2021
1	brivaracetamIBA 06/2021
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2021

Therapy/Procedure

9	Decompression 12/2023 - 10/2009
4	Laminectomy 04/2023 - 10/2017
3	Spinal Fusion (Spondylosyndesis) 10/2023 - 10/2010
3	Laminoplasty 12/2021 - 05/2009
1	Foraminotomy 12/2023
1	Osteotomy 10/2023
1	Length of Stay 06/2022
1	Kidney Transplantation 05/2021
1	Renal Replacement Therapy (Therapies, Renal Replacement) 05/2021
1	Pedicle Screws 01/2021